Smallpox is an infectious disease that affected humanity for a very long time. It was a big issue for the colonies. During the American Revolution the best way to fight against smallpox was through inoculation. Do you remember when Dr. Joseph Warren tried to inoculate Cam? Also, when we met Squanto, we learned that smallpox destroyed his entire village. Thankfully smallpox has been eradicated since 1979.
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